Understanding life at molecular level

Our research in the Laboratory of Structural Biology aims at understanding the structure and function of biological macromolecules and their complexes, such as those involved in cellular cargo transport, protein folding, cell-cell contacts and viral infection. We strive to decipher basic principles in their assembly and function by structural biology methods, notably cryogenic electron microscopy (cryo-EM). We are also actively developing computational data analysis and sample tagging and capture methods for cryo-EM. Detailed mechanistic understanding of proteins involved in disease is informing rational design of therapies. We are based in the Institute of Biotechnology, Helsinki Institute of Life Science HiLIFE.