Tutkitun tiedon teemavuosi 2021


Miten tutkittu tieto syntyy?
Tutkitun tiedon teemavuosi 2021 -nettisivut: https://tutkittutieto.fi/

Verkkoluento lauantaina 20.3.2021 klo 14.00-15.00 .

Uni on terveydelle tärkeää. Tämä ilmenee johdonmukaisesti väestöpohjaisissa ja laboratorioissa tehdyissä tutkimuksissa. Koska me kaikki nukumme, jokaisella yksilöllä on myös oma, selkeä käsityksensä unesta. Uni on kuitenkin monimutkainen prosessi, jonka kaikkia mekanismeja ja merkitystä ei vielä täysin tunneta.

SleepWell on Suomessa ensimmäinen kansainvälisen arvioinnin läpi käynyt yliopistollinen uneen keskittyvä tutkimusohjelma. SleepWell –tutkijat haluavat tässä tapahtumassa kertoa ymmärrettävällä tavalla unesta ja samalla purkaa erilaisia uneen liittyviä virheellisiä uskomuksia.

Kuusi puheenvuoroa

Yliopiston lehtori Henna-Kaisa Wigren

Myytti 1: "Unentarve on aina ja kaikille sama" - Yliopistonlehtori Henna-Kaisa Wigren, HY

Dosentti Tarja Stenberg

Myytti 2: ”Uni on vain aivoja varten” – Dosentti Tarja Stenberg, HY

Professori Anu-Katriina Pesonen

Myytti 3: ”Syvä uni on paras uni” – Professori Anu-Katriina Pesonen, HY

Professori Eija Kalso

Myytti 4: ” Kipu se vain unta häiritsee” - Professori Eija Kalso, HY

Professori Tiina Paunio

Myytti 5: ”Uni paranee, kun mielikin paranee” – Professori Tiina Paunio, HY

Apulaisprofessori Tomi Rantamäki

Myytti 6: ”Unilääkkeet hoitavat unihäiriöitä” – Apulaisprofessori Tomi Rantamäki, HY


The 6th Finnish Symposium on Biological Psychiatry

Please register and/or send your abstarct at

The 6th Finnish Symposium on Biological Psychiatry

The symposium will include:

  • Keynote lecture by Michael Eriksen Benros (University of Copenhagen)
  • Invited lecture by Salli Antila (University of Helsinki and Wihuri Research Institute):
    "Meningeal lymphatic vessels in the CNS function"

Small group discussion with experts:

  • William Hennah: Biomarkers in psychiatry
  • Leonard Khirug: Methods of in vivo imaging and electrophysiology in behaving animals
  • Anneli Kylliäinen: Autism spectrum disorders
  • Francesco Noe: Neuroimmunology
  • Hanna Ollilla: Genetics of sleep
  • Olli Pietiläinen: Genetics of schizophrenia

Short talks by young investigators, selected based on submitted abstracts. 

  • Aino Saarinen (Early adversity and processing of facial emotions: a meta-analysis)
  • Aleksi Kukkonen (Bisphenol A exposure during pregnancy, newborn methylation and behavioral problems in childhood: the PREDO study)
  • Sonja Sulkava (Genetic background of job-related exhaustion and its link to Alzheimer's disease)
  • Marja Koskuvi (Patient iPSC-astrocytes show transcriptional and functional dysregulation in schizophrenia)
  • Mikaela Laine (Differential gene expression response of oligodendrocytes and myelin to chronic psychosocial stress in C57BL/6NCrl and DBA/2NCrl mice)
  • Sarah Steffens (The impact of circadian rhythmicity and sleep-wake rhythms on microglia)

Target audience: Students, postdocs and faculty working on human genetic and imaging studies in psychiatric diseases, mechanisms of psychiatric diseases, including functional, pharmacological and genetic analyses in model organisms, and related fields. 

Credits (NEUBM-301): Students will receive 1 ECTS from attendance + submitting a 1 page essay on the scientific content of the symposium, or 2 ECTS by attendance + essay + short talk presentation.


Abstract submission deadline: 20.11.2020 
The deadline for registration without an abstract is November 27, 2020 

We hope to see you there!

Iiris Hovatta, PhD, professor of behavioral genetics      
Tiina Paunio, MD, PhD, professor of psychiatry
Maija Koskinen, MSc, doctoral student
Fatma Doagu, MSc, doctoral student              

Welcome to the first SleepWell Research Symposium


Prof Tiina Paunio

15.00-15.10 Professor, Program Director Tiina Paunio:
Opening of the symposium

Prof Eus Van Someren

15.10-15.50 Professor Eus van Someren, Netherlands Institute for Neuroscience:
Towards understanding mechanisms of insomnia   

Prof. Eus Van Someren was trained in physics, psychophysiology and neuropsychology and received a cum laude PhD in neurobiology from the faculty of medicine. He leads a team at the Netherlands Institute for Neuroscience, aiming to unravel brain mechanisms of chronic insomnia. He received prestigious grants including an ERC-AdG, and founded the Sleep Registry (sleepregistry.org) for rich phenotyping of over 10,000 volunteers. He (co)-authored on more than 250 peer-reviewed publications in scientific journals including NJEM, Jama, Nature Genetics, Nature Neuroscience, Lancet Psychiatry, Archives of General Psychiatry, Psychological Bulletin, Brain, Current Biology and PNAS and is widely cited (H-index 55). His informal infectious enthusiasm for a neuroscience of insomnia make him a frequently invited speaker, e.g. at TED-X.

Prof Larry D. Sanford

15.50-16.30  Professor Larry D Sanford, Eastern Virginia Medical School:
Fear conditioning, neuroimmune responses and sleep: Role of amygdala in mediating a complex relationship   

Larry D. Sanford, PhD, is Professor and Director of the Center for Integrative Neuroscience and Inflammatory Diseases and Vice Chair for Experimental Pathology in the Pathology and Anatomy Department at Eastern Virginia Medical School, Norfolk Virginia, USA. Dr. Sanford’s primary research program is focused on using animal models to understand the role interactions between sleep, stress, and fear learning and memory play in the development of PTSD and anxiety disorders. Other work examines the role that sleep plays in mediating the effects of stress and radiation during space flight, behavioral and neural regulation of neuroinflammation, and mechanisms of neural communication.

Prof Colin Espie

16.30-17.10 Professor Colin Espie, Oxford University:
How and why to treat insomnia?

I am Professor of Sleep Medicine in the Nuffield Department of Clinical Neurosciences (NDCN), University of Oxford where I founded the Experimental & Clinical Sleep Medicine research programme in the Sleep & Circadian Research Institute (SCNi) and I am Clinical Director of the Oxford Online Programme in Sleep Medicine  (https://www.ndcn.ox.ac.uk/study/graduate-students/online-programme-in-sl...). I am a Fellow of Somerville College, Oxford and a Senior Research Fellow in the University Department of Psychiatry.

17.10-17.20 Break

Prof Sara Aton

17.20-18:00 Professor Sara Aton, University of Michigan:
How sleep loss disrupts hippocampal memory mechanisms 

Dr. Sara Aton received her PhD from Washington University in St .Louis, and carried out postdoctoral work at the University of Pennsylvania with Dr. Marcos Frank. Her laboratory at the University of Michigan, established in 2012, has investigated two sleep-dependent phenomena - consolidation of fear memories in the mouse hippocampus, and consolidation of experience-dependent plasticity in mouse primary visual cortex. Work from her lab, combining in vivo electrophysiology with optogenetic and pharmacogenetic manipulations of brain circuits, has established the vital role for sleep-associated network oscillations in driving both processes. Current studies being carried out in the Aton lab are characterizing how learning experiences and subsequent sleep affect basic biochemical processes in specific neuronal cell types, excitatory/inhibitory balance, and the activity and plasticity of experience-activated  (i.e. engram) neurons.  

Prof Ruth Benca

18:00-18:40 Professor Ruth Benca, University of California, Irvine:
Sleep and Psychiatry

Dr. Ruth Benca is Professor and Chair, Department of Psychiatry and Human Behavior at the University of California, Irvine.  She received her AB at Harvard and her MD and PhD degrees from the University of Chicago. She has been a faculty member at the University of Chicago and the University of Wisconsin-Madison, where she was Associate Chair of the Psychiatry Department and Director of the UW Center for Sleep Medicine and Sleep Research. She moved to UC Irvine in 2016, where she has established a sleep medicine center providing clinical care for sleep disorders as well as promoting translational research. Her research focuses on the interface between sleep and psychiatric disorders across the lifespan, and the role of sleep and sleep disorders on Alzheimer’s disease. She has served as principal investigator for studies funded by agencies including the NIH and the DOD.  Her work has spanned basic research in animal models to clinical research and clinical trials. She has authored over 150 articles, reviews and book chapters. She has served as President of the Sleep Research Society and on the Board of Directors of the American Academy of Sleep Medicine, and currently is Editor-in-chief of Current Sleep Medicine Reports and Insomnia Section Editor of UpToDate.

European Sleep Science Award 2020

Dear Colleagues,  

It was my pleasure to present Dr. Tarja Porkka-Heiskanen – a sleep scientist, teacher, debater, and influencer in sleep medicine – with the European Sleep Science Award 2020 during the Welcome and Opening of the Virtual Edition of our 25th Congress of the European Sleep Research Society (22 Sept 2020). 

Dr. Porkka-Heiskanen received her medical degree in 1983 and her doctoral degree in 1990 from the University of Helsinki. She performed her postdoctoral studies during the 1990’s in the USA at Northwestern University and Harvard Medical school – spending two years at both. 

A central revelation by Dr. Porkka-Heiskanen related to homeostatic regulation of sleep, where she identified adenosine as a key regulatory molecule during her postdoctoral research in the lab of Robert W. McCarley. This finding was published in Science in 1997 and since then, it has been one of the central reports in sleep medicine that paved the path for many other roads in modern sleep research. 

Her interest in sleep research has been exceptionally wide; centered around the basic physiological mechanisms of sleep regulation, it has also extended to broader developmental dimensions –from early development to ageing, as well as to specific, gender-related aspects. She also pioneered studies on the consequences of sleep deprivation on the immune system. In 2018, Dr. PorkkaHeiskanen was awarded The Pisa Sleep Award

She has also had central roles in many international activities, including membership in the ESRS Education and Research Committees and Board, chairing the EU Committee and establishing the ESRS Forum for Women. She has acted on the Editorial Boards of several respected international sleep journals, including the Journal of Sleep Research. 

Regarding her contribution towards scientific collaboration, she has coordinated several sleepcentered international consortia and is particularly active in postgraduate education, both nationally and internationally. She established the notable Sleep School at the University of Helsinki, which recently turned into a combination of digital education and hands-on practice – all thanks to Tarja’s efforts. More recently, she pioneered future educational activity at ESRS by establishing the webbased education on basic sleep research, “eLessons”.

Tarja is still active at the University of Helsinki. She is one of our PIs for the SleepWell Research program – the first internationally evaluated research program oriented on sleep medicine at the faculty level in Finland.

As a colleague, she has been exceptionally supportive and innovative. At the same time, she is uncompromising in scientific integrity, logical thinking and scientific reasoning. 

Beyond scientific activities, as some of you might know, she is an excellent dancer; she loves her garden; she is an excellent writer (and could have accomplished a career as a writer if she had wished to do so) – and, most importantly she has an unfailing sense of humor.

Again, it was my great honor – and pleasure – to introduce Dr. Tarja Porkka-Heiskanen as the recipient of the European Sleep Science Award 2020. 

Thank you for your contributions towards the field of sleep science, the ESRS and your scientific collaboration and support of colleagues and young scientists.

Prof. Tiina Paunio

Neuroscience Center, HiLIFE, seminar through zoom 

ENCORE in Depression:
Synaptic Homeostasis, Plasticity, and Sleep Integrate Rapid Antidepressant Effects

Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, & SleepWell Research Program, Faculty of Medicine, University of Helsinki, Finland

Dr. Rantamäki and his team investigates neurobiological mechanisms underlying rapid antidepressant effects. In this seminar he will present their latest findings and recently formulated hypothesis called encoding, consolidation and renormalization in depression (ENCORE-D) that aims explaining rapid (and sustained) antidepressant effects of ketamine and related drugs beyond conventional pharmacology. The hypothesis suggests that rapid and sustained antidepressant effects rely on intrinsic homeostatic mechanisms evoked as a response to the acute pharmacological or physiologic effects (e.g. prominent synaptic potentiation) triggered by the treatment. The hypothesis incorporates elements from the synaptic homeostasis hypothesis (SHY) of sleep and suggests that the fundamental mechanisms of synaptic plasticity and sleep, particularly the homeostatic emergence of slow-wave EEG activity and the renormalization of synaptic strength, are at the center of sustaining antidepressant effects. ENCORE-D provides an interesting mechanistic framework for studying and developing rapid-acting antidepressants.

Selected publications

  1. Rantamäki T and Kohtala S: Encoding, consolidation and renormalization in Depression: Synaptic Homeostasis, Plasticity, and Sleep Integrate Rapid Antidepressant Effects. Pharmacological Reviews 72:1–27, 2020
  2. Kohtala S, Theilmann W, Rosenholm M, Penna P, Karabulut G, Uusitalo S, Järventausta K, Yli-Hankala A, Yalcin I, Matsui N, Wigren H-K and Rantamäki T: Cortical excitability and activation of TrkB signaling during rebound slow oscillations are critical for rapid antidepressant responses. Molecular Neurobiology 56:4163-4174, 2019 
  3. Kohtala S, Theilmann W, Rosenholm M, Müller HK, Kiuru P, Wegener G, Yli-Kauhaluoma J and Rantamäki T: Ketamine-induced regulation of TrkB-GSK3β signaling is accompanied by slow EEG oscillations and sedation but is independent of hydroxynorketamine metabolites. Neuropharmacology 157:107684, 2019
  4. Antila A, Ryazantseva M, Popova D, Sipilä P, Guirado R, Kohtala S, Vesa L, Lindholm J, Yalcin I, Sato V, Cordeira J, Autio H, Kislin M, Rios M, Joca S, Casarotto P, Khiroug L, Lauri S, Taira T, Castrén E and Rantamäki T: Isoflurane produces antidepressant effects and activates TrkB signaling in rodents. Scientific Report 7(1):7811, 2017. 
  5. Theilmann W, Alitalo O, Yorke I and Rantamäki T: Dose-dependent effects of isoflurane on TrkB and GSK3β signaling: importance of burst suppression pattern. Neuroscience Letters 694:29-33, 2019

Tiedekulma STA­GE

Ihmeellinen uni

Uni on terveydelle elintärkeää. Se luo perustan niin ihmisten kuin eläinten hyvinvoinnille ja oppimiselle. Unen puutteessa mieliala kärsii, suorituskyky laskee ja pidemmän päälle fysiologisista vaikutuksista voi seurata terveysongelmia. Mutta mitä uni oikeastaan on ja miten sitä tutkitaan? Miten eläinten uni liittyy ihmisten uneen?

Helsingin yliopiston unitutkijat tarkastelevat Tiedekulmassa unta ja nukkumista eri näkökulmista. Tapahtuman juontaa Reetta Räty.

Tapahtuma on osa Tiedekulman Helsinki Health Weekiä, joka vie sinut elämäntieteiden huippuosaamisen äärelle. Osallistu tapahtumaan paikan päällä, seuraa livestriimiä tai katso tallenne! Klikkaa itsesi mukaan tapahtumaan myös Facebookissa.


Mitä uni on? Kurkistus unen biologiaan
Henna-Kaisa Wigren, yliopistotutkija, unitutkimusryhmän nuorempi ryhmänjohtaja

Uni vasikan hyvinvoinnin mittana?
Laura Hänninen, kliininen opettaja, eläinlääketieteellinen tiedekunta

Ihmisen uni – mitä sillä tekee?
Liisa Kuula, kognitiotieteilijä, unitutkija

Masennuslääkkeet ja uni
Tomi Rantamäki, molekulaarisen farmakologian apulaisprofessori, farmasian tiedekunta


Tiedekulma Ihmeellinen uni puhujat

Laura Hänninen (@laurathanninen) on kliininen opettaja Eläinten hyvinvoinnin tutkimuskeskuksessa eläinlääketieteellisessä tiedekunnassa ja on eläinten hyvinvointiin ja käyttäytymiseen hurahtanut eläinlääkäri. “Eläinten käyttäytyminen on portti niiden mieleen, mahdollisuus saada, edes hämärästi, käsitys, mitä ne ajattelevat, mistä pitävät, mitä tuntevat”, hän sanoo. Vinkki terveyden ja hyvinvoinnin edistämiseen: “Riittävä uni! Nukun paljon, ja mielelläni.”

Tutkijatohtori Liisa Kuula (@LiisaKuula) on kognitiotieteilijä ja unitutkija Helsingin yliopistossa. Hän tutkii ihmisten nukkumista ja siihen liittyviä erilaisia ilmiöitä. Liisasta on merkillistä, että lähes kolmannes elämästämme kuluu unessa. Uni on edelleen tutkimuksellekin mysteeri, ja sen mahdista paljastuu koko ajan uutta tietoa. Tutkimusryhmänsä kanssa Liisa pyrkii löytämään syitä unen määrän, laadun ja ajoituksen vaihtelulle ja selvittämään, miten uneen voi vaikuttaa. Vinkki terveyden ja hyvinvoinnin edistämiseen: “Omaa uniterveyttään voi parantaa menemällä viikonloppuisin vartin aikaisemmin nukkumaan kuin arkisin – helppo ja halpa arvostuksen osoitus itselle.”

Tomi Rantamäki (@TomiRantamki) on molekulaarisen farmakologian apulaisprofessori farmasian tiedekunnassa ja mukana lääketieteellisen tiedekunnan SleepWell-tutkimusohjelmassa. Hän johtaa tutkimusryhmää, joka selvittää masennuslääkkeiden vaikutusten mekanismeja. Perinteisestä farmakologisesta ajattelusta poiketen tutkimusryhmä uskoo parhaiden vastausten löytyvän aivoista itsestään – siitä, miten aivot reagoivat hoitoihin. Erityisen kiehtovana Tomi pitää sitä, miten uni ja sen mekanismit liittyvät masennushoitojen toimintaan. Vinkki terveyden ja hyvinvoinnin edistämiseen: “Ole aktiivinen ja osallistuva, ja ennen kaikkea armollinen itsellesi.”

Henna-Kaisa Wigren on yliopistotutkija SleepWell-tutkimusohjelmassa ja unitutkimusryhmän nuorempi ryhmänjohtaja. Henna-Kaisa väittää, että aivojen toimintaa on mahdotonta ymmärtää tutkimalla pelkästään valvetta. Sen sijaan pitää ymmärtää, miksi vireystilat vuorottelevat ja miten aivojen tiedonkäsittely muuttuu unen ja valveen välillä. Erityisesti häntä kiinnostaa, miksi uni on elintärkeää ja miksi unta tai unenkaltaista tilaa esiintyy kaikilla lajeilla. Vinkki terveyden ja hyvinvoinnin edistämiseen: “Kun tekee valveilla ollessaan intensiivisesti aivoja haastavia asioita, jotka tuottavat mielihyvää, tulee samalla vahvistaneeksi luonnollisen unipaineen kertymistä ja silloin uni on yöllä syvempää, pidempää ja palauttavampaa.”

Studia Medicina -yleisöluento:
Hyvä, paha stressi

  • klo 17.00-17.30 Professori Iiris Hovatta, HY: Stressin fysiologiaa
  • klo 17.30-18.00 Akatemiaprofessori Katri Räikkönen-Talvitie, HY: Elämän alkuvaiheen stressi
  • klo 18.00-18.30 Professori, ylilääkäri Tiina Paunio, HY, HUS: Kuinka hallita stressiä?
  • klo 18.30-19.00 Yleisökysymykset ja keskustelu

Kahvitarjoilu klo 16.00
Vapaa pääsy. Tervetuloa!

Aika: ke 15.1.2020 17.00-19.00
Paikka: Biomedicum Helsinki 1, luentosali 1
Osoite: Meilahti, Haartmaninkatu 8, Helsinki
Järjestäjä: Biomedicum Helsinki -säätiö, Helsingin ja Uudenmaan sairaanhoitopiiri ja HY lääketieteellinen tdk

The 5th Finnish Symposium on Biological Psychiatry

University of Helsinki, Meilahti campus, Haartmaninkatu 3, Lecture hall 1 

5th Finnish Biological Psychiatry Symposium website

The symposium will include:

Keynote lecture by 
Prof. Hee-Sup Shin (Institute for Basic Science, Republic of Korea): Genetic and circuitry analysis of affective empathy 

Talks by leading Finnish investigators in biological psychiatry
Prof. Tiina Paunio 
Dr Jari Lahti
Dr Tuukka Raij

Short talks by young investigators, selected based on submitted abstracts.

  • Authors of selected abstracts will be notified by 2.12. 
  • Posters selected based on submitted abstracts. 

Target audience: Students, postdocs and faculty working on human genetic and imaging studies in psychiatric diseases, mechanisms of psychiatric diseases, including functional, pharmacological and genetic analyses in model organisms, and related fields. 

Credits (NEUBM-301): Students will receive 1 ECTS from attendance + submitting a 1 page essay on the scientific content of the symposium, or 2 ECTS by attendance + poster/oral presentation + essay. 

We hope to see you there!
Iiris Hovatta, PhD, professor of behavioral genetics      
Tiina Paunio, MD, PhD, professor of psychiatry
Mikaela Laine, MSc, doctoral student                               
Fatma Doagu, MSc, doctoral student



  • On Friday 27.9.2019 our program invited associates and co-workers to celebrate our labs at Haartman institute.
    Speeches were given, toasts were raised and general mood was high!
    Thanks to all the participants!