From prostatic proteases to the roles of glycosylation in reproduction
By studying prostatic proteases, we aim to identify novel prostate cancer markers and drug targets. This involves development of novel patient-derived tissue and cell models, addressing also the role of tumor microenvironment, and is underpinned by a wide international collaborative network. Our collaborative studies are extended also to reproductive biology and the role of protein glycosylation in functions of glycodelin. Based on these studies, glycodelin is currently considered as one of the foremost examples of how glycosylation dictates the function(s) of a glycoprotein. Apart from the functional studies, we perform different marker studies, e.g., using several immunoassays we have established. Currently one of our major interests is to establish methods for cancer specific glycoforms of glycoprotein markers to improve their specificity for detection of cancer.