Genome Stability Group
Our research focuses on understanding how cells maintain integrity of their genomes in the face of internal and external damage, originating e.g. during DNA replication or upon exposure to chemotherapeutic agents. We use both basic science and translational approaches, the latter concentrating on high-grade serous ovarian cancer patient samples. Our aim is to provide biological insights that will be useful in clinical decision-making, either immediately or in the longer term.
As cells divide, they must ensure that each daughter cell receives the correct number of chromosomes. In healthy cells, two major...
Our research focuses on: 1. DNA rearrangements in tumor cells 2. Mismatch repair and tandem repeat instability 3. Role of DNA re...