The characterization of antimicrobial resistant bacteria aids in determining the traits carried by successful antimicrobial resistant bacteria, and also gives insight into potential zoonotic transmission routes. In this study whole genome sequencing is used to characterize ESBL-producing Escherichia coli isolates from clinical human samples from Finland. These isolates are then compared to previously sequenced ESBL/AmpC-producing E. coli isolates from various non-human sources from Finland, including animal, food, and environmental sources, to assess the potential similarities and differences between the isolates. The antimicrobial resistance and virulence genes, bacterial sequence types, and plasmid replicons are compared to investigate the potential zoonotic connections.
The study has received funding from the Finnish Foundation for Veterinary Research and the Doctoral School of Environmental, Food and Biological Sciences in University of Helsinki.