Publications

Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments

Sarang S. Talwelkar, Mikko I. Mäyränpää, Lars Søraas, Swapnil Potdar, Jie Bao, Annabrita Hemmes, Nora Linnavirta, Jon Lømo, Jari Räsänen, Aija Knuuttila, Krister Wennerberg, Emmy W. Verschuren,
Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments,
Cell Reports Medicine, Volume 2, Issue 8, 2021, [100373], doi: 10.1016/j.xcrm.2021.100373

SOX9 has distinct roles in the formation and progression of different non-small cell lung cancer histotypes

Bao, J., Närhi, K., Teodosio, A., Hemmes, A., Linnavirta, N. M., Mäyränpää, M., Salmenkivi, K., Le Quesne, J., & Verschuren, E. W. (2021). SOX9 has distinct roles in the formation and progression of different non-small cell lung cancer histotypes. Journal of Pathology, [105276]. doi: 10.1002/path.5733

Spa-RQ: an Image Analysis Tool to Visualise and Quantify Spatial Phenotypes Applied to Non-Small Cell Lung Cancer

Bao, J., Walliander, M., Kovacs, F., Nagaraj, A. S., Hemmes, A., Sarhadi, V. K., ... Verschuren, E. W. (2019). Spa-RQ: an Image Analysis Tool to Visualise and Quantify Spatial Phenotypes Applied to Non-Small Cell Lung Cancer. Scientific Reports9, [17613]. doi: 10.1038/s41598-019-54038-9.

Receptor Tyrosine Kinase Signaling Networks Define Sensitivity to ERBB Inhibition and Stratify Kras Mutant Lung Cancers

Talwelkar, S. S., Nagaraj, A. S., Devlin, J. R., Hemmes, A., Potdar, S., Kiss, E. A., ... Verschuren, E. (2019). Receptor Tyrosine Kinase Signaling Networks Define Sensitivity to ERBB Inhibition and Stratify Kras Mutant Lung Cancers. Molecular Cancer Therapeutics18(10), 1863-1874. doi: 10.1158/1535-7163.MCT-18-0573.

Establishment and Analysis of Tumor Slice Explants As a Prerequisite for Diagnostic Testing

Nagaraj, A. S., Bao, J., Hemmes, A., Machado, M., Närhi, K., & Verschuren, E. W. (2018). Establishment and Analysis of Tumor Slice Explants As a Prerequisite for Diagnostic Testing. Journal of Visualized Experiments141, [ e58569]. doi: 10.3791/58569.

Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras-driven lung tumours

Närhi, K., Nagaraj, A. S., Parri, E., Turkki, R., van Duijn, P. W., Hemmes, A., ... Verschuren, E. W. (2018). Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras-driven lung tumours. Journal of Pathology245(1), 101-113. doi: 10.1002/path.5059.

Cell of Origin Links Histotype Spectrum to Immune Microenvironment Diversity in Non-small-Cell Lung Cancer Driven by Mutant Kras and Loss of Lkb1

Nagaraj, A. S., Lahtela, J., Hemmes, A., Pellinen, T., Blom, S., Devlin, J. R., ... Verschuren, E. W. (2017). Cell of Origin Links Histotype Spectrum to Immune Microenvironment Diversity in Non-small-Cell Lung Cancer Driven by Mutant Kras and Loss of Lkb1. Cell Reports18(3), 673-684. doi: 10.1016/j.celrep.2016.12.059.

Capturing complex tumour biology in vitro: histological and molecular characterisation of precision cut slices

Davies, E., Dong, M., Gutekunst, M., Narhi, K., van Zoggel, H. J. A. A., Blom, S., ... Hickman, J. A. (2015). Capturing complex tumour biology in vitro: histological and molecular characterisation of precision cut slices. Scientific Reports5, [17187]. doi: 10.1038/srep17187.

The putative tumor suppressor gene EphA3 fails to demonstrate a crucial role in murine lung tumorigenesis or morphogenesis

Jenni Lahtela, Barun Pradhan, Katja Närhi, Annabrita Hemmes, Merja Särkioja, Panu E. Kovanen, Arthur Brown, Emmy W. Verschuren. The putative tumor suppressor gene EphA3 fails to demonstrate a crucial role in murine lung tumorigenesis or morphogenesis. Disease Models & Mechanisms 2015 8: 393-401; doi: 10.1242/dmm.019257.

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Closing chapter in the upcoming book "Rethinking Cancer: A new Paradigm for the Postgenomics Era"

Edited by Bernhard Strauss, Marta Bertolaso, Ingemar Ernberg, and Mina J. Bissell

The MIT Press, Cambridge Massachusetts & London, England

Emmy W. Verschuren "Niche Reconstruction to Revert or Transcend the Cancer State”