The Jokitalo group studies structure-function interplay of organelles in mammalian cells. Our main model organelle is the endoplasmic reticulum. We employ a wide range of basic biological techniques and advanced imaging techniques, and have developed imaging software for multidimensional imaging. Our research can shed light on the connection between the endoplasmic reticulum and many diseases, such as Alzheimer's disease and Hereditary spastic paraplegia.