Organelle Biogenesis, Dysfunction, and Evolution Laboratory
Principal Investigator Cory Dunn
Our laboratory is focused upon three major topics, and we take advantage of both yeast and human cell culture. First, we examine how proteins synthesized by the cell make their way to mitochondria and peroxisomes. Second, we have developed a keen interest in understanding organellar evolution. Specifically, we focus upon selection within the mitochondrial genome and upon events that occurred during conversion of the proto-mitochondrial endosymbiont to an organelle. Third, we study the consequences of organelle damage at the cellular level. One long term aim of our laboratory is to help develop treatments for metabolic disease.
Our laboratory takes a multidisciplinary approach to the study of organelle biology. We deploy cell biological, molecular genetic, high-...