Molecular Systems Biology
Our longstanding interest is the global and comprehensive understanding of how key cellular signaling molecules; protein kinases, protein phosphatases and transcription factors mediate their signaling potential and how the signaling is changed in diseases in the immuno-oncology axis. For this purpose, we have developed experimental and computational methods to identify the protein-interactions formed by these signaling molecules. Additionally, we employ quantitative mass spectrometry -based proteomics on assessing the protein abundance changes, as well as phosphorylation status of the tissues/cells. Furthermore, combining the data from the different sets of ‘omics’ data (proteomics, HTS and HiSeq), allows us to generate global and systems level understanding on how disease-causing mutations mediate their effects, enabling also the development of therapeutic or diagnostic approaches.
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Finding the molecular mechanisms behind diseases.
Recipe for success - interaction proteomics become a household item
A research team from University of Helsinki introduces a new optimised and integrated interaction proteomics protocol that combines two state-of...
In the fast lane for drug discovery
To date, no specific vaccines or antiviral drugs have been developed for SARS-CoV-2. Drug discovery is hindered by the fact that viruses do not...
In our “Molecular Systems Biology Research Group” we have taken a systems-biology approach to understand how important cellular signalling...