Varjosalo Lab

Our longstanding interest is the global and comprehensive understanding of how key cellular signaling molecules; protein kinases, protein phosphatases and transcription factors mediate their signaling potential and how the signaling is changed in diseases in the immuno-oncology axis. For this purpose, we have developed experimental and computational methods to identify the protein-interactions formed by these signaling molecules. Additionally, we employ quantitative mass spectrometry -based proteomics on assessing the protein abundance changes, as well as phosphorylation status of the tissues/cells. Furthermore, combining the data from the different sets of ‘omics’ data (proteomics, HTS and HiSeq), allows us to generate global and systems level understanding on how disease-causing mutations mediate their effects, enabling also the development of therapeutic or diagnostic approaches.

News and Twitter

Finding the molecular mechanisms behind diseases.
@Varjosalo_Lab

Look what the Santa brought us! 💪🏻 @HiLIFE_helsinki @BIOTECH_UH @SuomenAkatemia @helsinkiuni @BrukerMassSpectwitter.com/i/web/status/1…

Our RTK article out as preprint: papers.ssrn.com/sol3/papers.cf… @Varjosalo_Lab @BIOTECH_UH @HiLIFE_helsinki @helsinkiuni @CellReports

Our work on TFs out now as #preprint on @researchsquare: Human transcription factor protein interaction networks… twitter.com/i/web/status/1…

New paper out: Molecular pathogenesis of rhegmatogenous retinal detachment @SciReports. #Massspectrometry of vitreo… twitter.com/i/web/status/1…