PUBLICATIONS

SELECTED PUBLICATIONS

Research articles:

Viitanen, A., Gullmets, J.,  Morikka, J., Katajisto, P.,  Mattila, J & Hietakangas, V. An image analysis method for regionally defined cellular phenotyping of the Drosophila midgut. Cell Reports Methods July 30, 2021

Here we have developed a powerful tool for organ-wide quantitative analysis of the regional heterogeneity of midgut cells.

Liu, Y., Mattila, J & Hietakangas, V. Systematic Screen for Drosophila Transcriptional Regulators Phosphorylated in Response to Insulin/mTOR Pathway. G3: Genes, Genomes, Genetics August 1, 2020 vol. 10 no. 8:2843-2849

Here we have cloned a library of 850 Drosophila transcriptional regulators and used it to screen mediators of the Insulin-mTOR network. In case you are interested in using our library for screenings, do not hesitate to contact.

Mattila, J., Kokki, K., Hietakangas, V. & Boutros, M. Stem cell intrinsic hexosamine metabolism regulates intestinal adaptation to nutrient content. Dev Cell. 2018 47(1):112-121

Here we show that intestinal tissue plasticity is dependent on the glucose metabolizing hexosamine synthesis pathway. The work is previewed by Beebe & Thummel Dev Cell 2018 47(1).

Mattila, J., Havula, E., Suominen, E., Teesalu, M., Surakka, I., Hynynen, R., Kilpinen, H., Väänänen, J., Hovatta, I., Käkelä, R., Ripatti, S., Sandmann, T. & Hietakangas, V.  Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe. Cell Rep. 2015 Oct 13;13(2):350-64

Mattila, J., Kallijärvi, J. & Puig, O.: RNAi screening for kinases and phosphatases identifies FoxO regulators. Proc Natl Acad Sci USA 2008 105(39):14873-8

Mattila, J., Omelyanchuk, L., Kyttälä, S., Turunen, H. & Nokkala, S.: Role of Jun N-terminal Kinase (JNK) signaling in the wound healing and regeneration of Drosophila melanogaster wing imaginal disc. Int J Dev Biol 2004 49: 391-399

Reviews:

Mattila & Hietakangas, V.: FlyBook: Regulation of carbohydrate energy metabolism in Drosophila melanogaster. Genetics 2017 207(4) 1231:1253

Puig, O. & Mattila, J.: Understanding Forkhead box class O function: lessons from Drosophila melanogaster. Antioxid Redox Signal 2011 14(4): 635-647

Full list of publications can be found here.