The EV group studies extracellular vesicles (EVs), submicron membrane vesicles released by most cells (mammalians to prokaryotes), that are present in all body fluids, but also e.g., in oceans. Since EVs shuttle parent cell -derived molecules (proteins, lipids,metabolites and nucleic acids) to other cells changing their phenotype and function, they can be described as extracellular organelles with a communicative function. The physiological role of EVs centers on heterogeneous cell communication, but EVs may provide cells with a homeostatic way for self-regulation by e.g., disposing of unwanted material. The dynamic molecular reservoir of EVs present a unique way for cells to regulate multicellular stepwise processes such as immune surveillance, blood coagulation, wound healing, angiogenesis and tissue regeneration. In diseases from cardiovascular to cancer, EVs similarly mediate mechanistic processes critical for pathogenesis.
EV group is part of the Cancer Unit for Research for Expermental Drugs (CURED)
