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Extracellular vesicles in health and disease

Eukaryotic and prokaryotic cells produce minute (40-1000 nm) membrane vesicles that are released into the local environment. These extracellular vesicles (EVs), including exosomes and microvesicles, contain a multi-molecular cargo of proteins, nucleic acids, lipids and metabolites. Together with the number of EVs, this “EVome” reflects the state of the organism and is subject to change upon environmental cues and the activation state of the cell. EVs may thus target recipient cells by e.g. the transfer of genomic material, or influence them by signaling lipids in the EV membrane. EVs have already been shown to function in various roles of cell-cell communication, in processes ranging from the regulation of immune responses – both good and bad – to cancer metastasis. The novel mechanism of cell signaling via EVs is a hot topic of contemporary cell biology. At the same time, there is a fast increasing interest in the use of EVs in diagnostics (liquid biopsies), therapeutics, and in drug delivery. The composition and quantity of EVs changes in many diseases, and is actively studied in cancer, opening possibilities for the use of EVs as early diagnostic or prognostic indicators. Furthermore, EVs may carry much of the therapeutic potential of stem cells and could be utilized in the treatment of complex diseases.

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Guess who got some new equipment last week? Woop woop! https://t.co/7wZTPOHMdS

Our group enjoyed beautiful weather while hiking on Friday in Lammassaari. @helsinkiuni @LifeSciHelsinki https://t.co/HKzP4KfDha

So much exiting science at #ISEV2021! Looking forward to this week 👩🏼‍🔬. And if you are interested on how to finetu… twitter.com/i/web/status/1…

#Exoview has arrived home! Looking forward to start working with it 😎 https://t.co/0jxuJ6gk4B

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