Marja Mikkola group
Many events that shape the developing animal embryos involve rearrangements of simple epithelial sheets into more complex three-dimensional structures, a process termed epithelial morphogenesis. Epithelial organ development is achieved through inductive interactions between different tissue types, typically between epithelial and mesenchymal tissues. Although the signaling pathways regulating epithelial-mesenchymal crosstalk have been largely identified, our understanding on how these signaling activities are translated into coordinated changes in cell behavior: proliferation, apoptosis, migration, or adhesion, is still rudimentary. Dissecting the details of organogenesis will be important for understanding the causes and developing cures when things go wrong as seen in developmental disorders or in tumorigenesis, as well as for advancing methods for organ regeneration.
One of the big questions in developmental biology is: how do cells of the embryo get organized into tissues and organs? Organogenesis...
Recent Publications Lan, Q. & Mikkola, M. L. Protocol: Adeno-Associated Virus-Mediated Gene Transfer in Ex Vivo Cultured Embryonic...
2020 Mushroom picking 2020 Summer Lab outing 2019 Lab summer retreat and Riitta's farewell 2018...
Vera Shirokova, 2016 Maria Voutilainen, 2015 Otso Häärä, 2013 Sylvie Lefebvre, 2012 Katja Närhi, 2012 Marja Pummila, 2009