Epithelial morphogenesis – from molecular pathways to cellular behavior

Many events that shape the developing animal embryos involve rearrangements of simple epithelial sheets into more complex three-dimensional structures, a process termed epithelial morphogenesis. Epithelial organ development is achieved through inductive interactions between different tissue types, typically between epithelial and mesenchymal tissues. Although the signaling pathways regulating epithelial-mesenchymal crosstalk have been largely identified, our understanding on how these signaling activities are translated into coordinated changes in cell behavior: proliferation, apoptosis, migration, or adhesion, is still rudimentary. Dissecting the details of organogenesis will be important for understanding the causes and developing cures when things go wrong as seen in developmental disorders or in tumorigenesis, as well as for advancing methods for organ regeneration.
Contact Marja Mikkola to learn more about our research and vacancies.

Congrats @8makela for the Finnish Cultural Foundation grant! #skr2021 https://t.co/gptLezJe3d

Grateful for being awarded a Finnish Cultural Foundation grant for my PhD work in @MikkolaLab Thank you #skr2021!

Very proud of @sqianglan for this great method of AAV-mediated gene transfer paper in @Mammary_journal! twitter.com/Mammary_journa…

Mikkola lab on a mushroom hunt! We hope to see everyone back tomorrow. https://t.co/fA4r77qHQX