2023
Comprehensive characterization of the embryonic factor LEUTX. Gawriyski L, Jouhilahti EM, Yoshihara M, Fei L, Weltner J, Airenne TT, Trokovic R, Bhagat R, Tervaniemi MH, Murakawa Y, Salokas M, Liu X, Miettinen S, Bürglin TR, Sahu B, Otonkoski T, Johnson MS, Katayama S, Varjosalo M, Kere J. iScience 2023 (open access)
2022
A competitive precision CRISPR method to identify the fitness effects of transcription factor binding sites. Pihlajamaa P, Kauko O, Sahu B, Kivioja T, Taipale J. Nature Biotechnology 2022 (open access)
Sequence determinants of human gene regulatory elements. Sahu B, Hartonen T, Pihlajamaa P, Wei B, Dave K, Zhu F, Kaasinen E, Lidschreiber K, Lidschreiber M, Daub CO, Cramer P, Kivioja T, Taipale J. Nature Genetics 2022 (open access)
2021
Compressive Stress-Mediated p38 Activation Required for ERα+ Phenotype in Breast Cancer. Munne PM, Martikainen L, Räty I, Bertula K, Nonappa N, Ruuska J, Ala-Hongisto H, Peura A, Hollmann B, Euro L, Patrikainen L, Salmela M, Yavuz K, Pokki J, Kivento M, Väänänen J, Suomi T, Nevalaita L, Mutka M, Kovanen P, Leidenius M, Meretoja T, Hukkinen K, Monni M, Pouwels J, Sahu B, Mattson J, Joensuu H, Heikkilä P, Elo L, Metcalfe C, Junttila MR, Ikkala O, Klefström J. Nature Communications 2021 (open access)
Human cell transformation by combined lineage conversion and oncogene expression. Sahu B, Pihlajamaa P, Zhang K, Palin K, Ahonen S, Cervera A, Ristimaki A, Aaltonen LA, Hautaniemi S, Taipale J. Oncogene 2021 (open access)
Deficient H2A.Z deposition is associated with genesis of uterine leiomyoma. Berta DG, Kuisma H, Välimäki N, Räisänen M, Jäntti M, Pasanen A, Karhu A, Kaukomaa J, Taira A, Cajuso T, Nieminen S, Penttinen RM, Ahonen S, Lehtonen R, Mehine M, Vahteristo P, Jalkanen J, Sahu B, Ravantti J, Mäkinen N, Rajamäki K, Palin K, Taipale J, Heikinheimo O, Bützow R, Kaasinen E, Aaltonen LA. Deficient H2A.Z deposition is associated with genesis of uterine leiomyoma. Nature 2021
2019
Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy. Göös H*, Fogarty CL*, Sahu B*, Plagnol V, Rajamäki K, Nurmi K, Liu X, Einarsdottir E, Jouppila A, Pettersson T, Vihinen H, Krjutskov K, Saavalainen P, Järvinen A, Muurinen M, Greco D, Scala G, Curtis J, Nordström D, Flaumenhaft R, Vaarala O, Kovanen PE, Keskitalo S, Ranki A, Kere J, Lehto M, Notarangelo LD, Nejentsev S, Eklund KK, Varjosalo M, Taipale J, Seppänen MRJ. The Journal of Allergy and Clinical Immunology 2019
2018
The interaction landscape between transcription factors and the nucleosome. Zhu F, Farnung L, Kaasinen E, Sahu B, Yin Y, Wei B, Dodonova SO, Nitta KR, Morgunova E, Taipale M, Cramer P, Taipale J. Nature 2018
Contribution of allelic imbalance to colorectal cancer. Palin K*, Pitkänen E*, Turunen M*, Sahu B*, Pihlajamaa P*, Kivioja T*, Kaasinen E, Välimäki N, Hänninen UA, Cajuso T, Aavikko M, Tuupanen S, Kilpivaara O, van den Berg L, Kondelin J, Tanskanen T, Katainen R, Grau M, Rauanheimo H, Plaketti RM, Taira A, Sulo P, Hartonen T, Dave K, Schmierer B, Botla S, Sokolova M, Vähärautio A, Gladysz K, Ongen H, Dermitzakis E, Bramsen JB, Ørntoft TF, Andersen CL, Ristimäki A, Lepistö A, Renkonen-Sinisalo L, Mecklin JP, Taipale J, Aaltonen LA. Nature Communications 2018
A protein activity assay to measure global transcription factor activity reveals determinants of chromatin accessibility. Wei B, Jolma A, Sahu B, Orre LM, Zhong F, Zhu F, Kivioja T, Sur I, Lehtiö J, Taipale M, Taipale J. Nature Biotechnology 2018
2017
Characterization of an androgen-responsive, ornithine decarboxylase-related protein in mouse kidney. Silander KM, Pihlajamaa P, Sahu B, Jänne OA, Andersson LC. Bioscience Reports 2017
Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Science 2017
Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes. Kaustio M, Haapaniemi E, Göös H, Hautala T, Park G, Syrjänen J, Einarsdottir E, Sahu B, Kilpinen S, Rounioja S, Fogarty CL, Glumoff V, Kulmala P, Katayama S, Tamene F, Trotta L, Morgunova E, Krjutškov K, Nurmi K, Eklund K, Lagerstedt A, Helminen M, Martelius T, Mustjoki S, Taipale J, Saarela J, Kere J, Varjosalo M, Seppänen M. The Journal of Allergy and Clinical Immunology 2017
2016
PeakXus: comprehensive transcription factor binding site discovery from ChIP-Nexus and ChIP-Exo experiments. Hartonen T, Sahu B, Dave K, Kivioja T, Taipale J. Bioinformatics 2016
2015
Androgen receptor- and PIAS1-regulated gene programs in molecular apocrine breast cancer cells. Malinen M, Toropainen S, Jääskeläinen T, Sahu B, Jänne OA, Palvimo JJ. Molecular and Cellular Endocrinology 2015
Determinants of Receptor- and Tissue-Specific Actions in Androgen Signaling. Pihlajamaa P, Sahu B, Jänne OA. Endocrine Reviews 2015
Identification of several potential chromatin binding sites of HOXB7 and its downstream target genes in breast cancer. Heinonen H, Lepikhova T, Sahu B, Pehkonen H, Pihlajamaa P, Louhimo R, Gao P, Wei GH, Hautaniemi S, Jänne OA, Monni O. International Journal of Cancer 2015
SUMO ligase PIAS1 functions as a target gene selective androgen receptor coregulator on prostate cancer cell chromatin. Toropainen S, Malinen M, Kaikkonen S, Rytinki M, Jääskeläinen T, Sahu B, Jänne OA, Palvimo JJ. Nucleic Acids Research 2015
2014
Androgen receptor uses relaxed response element stringency for selective chromatin binding and transcriptional regulation in vivo. Sahu B*, Pihlajamaa P*, Dubois V, Kerkhofs S, Claessens F, Jänne OA. Nucleic Acids Research 2014
Tissue-specific pioneer factors associate with androgen receptor cistromes and transcription programs. Pihlajamaa P*, Sahu B*, Lyly L, Aittomäki V, Hautaniemi S, Jänne OA. The EMBO Journal 2014
2013
Genomic region operation kit for flexible processing of deep sequencing data. Ovaska K, Lyly L, Sahu B, Jänne OA, Hautaniemi S. IEEE/ACM Transactions on Computational Biology and Bioinformatics 2013
FoxA1 specifies unique androgen and glucocorticoid receptor binding events in prostate cancer cells. Sahu B, Laakso M, Pihlajamaa P, Ovaska K, Sinielnikov I, Hautaniemi S, Jänne OA. Cancer Research 2013
2012
Androgen-regulated miR-32 targets BTG2 and is overexpressed in castration-resistant prostate cancer. Jalava SE, Urbanucci A, Latonen L, Waltering KK, Sahu B, Jänne OA, Seppälä J, Lähdesmäki H, Tammela TL, Visakorpi T. Oncogene 2012
Overexpression of androgen receptor enhances the binding of the receptor to the chromatin in prostate cancer. Urbanucci A, Sahu B, Seppälä J, Larjo A, Latonen LM, Waltering KK, Tammela TL, Vessella RL, Lähdesmäki H, Jänne OA, Visakorpi T. Oncogene 2012
2011
Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer. Sahu B, Laakso M, Ovaska K, Mirtti T, Lundin J, Rannikko A, Sankila A, Turunen JP, Lundin M, Konsti J, Vesterinen T, Nordling S, Kallioniemi O, Hautaniemi S, Jänne OA. The EMBO Journal 2011
Cytoplasmic accumulation of incompletely glycosylated SHBG enhances androgen action in proximal tubule epithelial cells. Hong EJ, Sahu B, Jänne OA, Hammond GL. Molecular Endocrinology 2011
2010
Androgen receptor and androgen-dependent gene expression in lung. Mikkonen L, Pihlajamaa P, Sahu B, Zhang FP, Jänne OA. Molecular and Cellular Endocrinology 2010
2009
Increased expression of androgen receptor sensitizes prostate cancer cells to low levels of androgens. Waltering KK, Helenius MA, Sahu B, Manni V, Linja MJ, Jänne OA, Visakorpi T. Cancer Research 2009