Publications

Doctoral Thesis

• Anil Palikhe MD, PhD, 2008 “ MHC region and coronary heart disease”.
• Riitta Paakkanen MD, PhD 2013 “Major Histocompatibility Complex Genes – Method of Analysis, Association with Acute Coronary Syndromes and Effect on Immune Reactions”.
• Harri Lindholm MD, PhD 2013 “Physiological determinants and assessment of stress and recovery among media workers”.
• Efthymia Vlachopoulou PhD 2015 ”Statistical aspects of MHC-region genetics in coronary artery disease”.
• Satu Vaara MD, PhD 2017 ”Clinical and genetical factors affecting causes of death in acute coronary syndrome”.
• Olavi Parkkonen MD, PhD 2017 “Takotsubo-cardiomyopathy: etiology and pathophysiology”.

Recent publications

• Allonen J, Nieminen MS, Hiippala S, Sinisalo J. Relation of Use of Red Blood Cell Transfusion After Acute Coronary Syndrome to Long-Term Mortality. AJC in press.
• Olkkonen VM, Sinisalo J, Jauhiainen M. New medications targeting triglyceride-rich lipoproteins: Can inhibition of ANGPTL3 or apoC-III reduce the residual cardiovascular risk? Atherosclerosis. 2018 Mar 8;272:27-32. [Epub ahead of print] Review
• Liljestrand JM, Paju S, Pietiäinen M, Buhlin K, Persson GR, Nieminen MS, Sinisalo J, Mäntylä P, Pussinen PJ. Immunologic burden links periodontitis to acute coronary syndrome. Atherosclerosis. 2018 Jan;268:177-184
• Martinez-Majander N, Aarnio K, Pirinen J, Lumikari T, Nieminen T, Lehto M, Sinisalo J, Kaste M, Tatlisumak T, Putaala J. Embolic strokes of undetermined source in young adults: baseline characteristics and long-term outcome. Eur J Neurol. 2017 Dec 7. doi: 10.1111/ene.13540. [Epub ahead of print]
• Salminen A, Vlachopoulou E, Havulinna AS, Tervahartiala T, Sattler W, Lokki ML, Nieminen MS, Perola M, Salomaa V, Sinisalo J, Meri S, Sorsa T, Pussinen PJ. Genetic Variants Contributing to Circulating Matrix Metalloproteinase 8 Levels and Their Association With Cardiovascular Diseases: A Genome-Wide Analysis. Circ Cardiovasc Genet. 2017 Dec;10(6). pii: e001731
• Tolva J, Paakkanen R, Jarva H, Pussinen P, Havulinna AS, Salomaa V, Sinisalo J, Lokki ML. Soluble HLA-DR serum levels are associated with smoking but not with acute coronary syndrome. Atherosclerosis. 2017 Nov;266:58-63.
• Saleheen D, Zhao W, Young R, Nelson CP, Ho WK, Ferguson JF, Rasheed A, Ou K, Nurnberg ST, Bauer RC, Goel A, Do R, Stewart AFR, Hartiala J, Zhang W, Thorleifsson G, Strawbridge RJ, Sinisalo J, Kanoni S, Sedaghat S, Marouli E, Kristiansson K, Zhao JH, Scott R, Gauguier D, Shah SH, Smith AV, Van Zuydam N, Cox AJ, Willenborg C, Kessler T, Zeng L, Province MA, Ganna A, Lind L, Pedersen NL, White CC, Joensuu A, Kleber ME, Hall AS, März W, Salomaa V, O'Donnell C, Ingelsson E, Feitosa MF, Erdmann J, Bowden DW, Palmer CNA, Gudnason V, de Faire U, Zalloua P, Wareham N, Thompson JR, Kuulasmaa K, Dedoussis G, Perola M, Dehghan A, Chambers JC, Kooner J, Allayee H, Deloukas P, McPherson R, Stefansson K, Schunkert H, Kathiresan S, Farrall M, Frossard PM, Rader DJ, Samani N, Reilly MP; EPIC-CVD.; PROMIS.; CARDIoGRAMplusC4D. Loss of Cardio-Protective Effects at the ADAMTS7 Locus Due to Gene-Smoking Interactions. Circulation. 2017 May 1. [Epub ahead of print].
• Parkkonen O, Nieminen MT, Vesterinen P, Tervahartiala T, Perola M, Salomaa V, Jousilahti P, Sorsa T, Pussinen PJ, Sinisalo J. Low MMP-8/TIMP-1 reflects left ventricle impairment in takotsubo cardiomyopathy and high TIMP-1 may help to differentiate it from acute coronary syndrome. PLoS One. 2017;12(3):e0173371.
• Hartman O, Kovanen PT, Lehtonen J, Eklund KK, Sinisalo J. Hydroxychloroquine for the prevention of recurrent cardiovascular events in myocardial infarction patients: rationale and design of the OXI trial. Eur Heart J Cardiovasc Pharmacother. 2017;3(2):92-97.
• Laaksonen R, Ekroos K, Sysi-Aho M, Hilvo M, Vihervaara T, Kauhanen D, Suoniemi M, Hurme R, März W, Scharnagl H, Stojakovic T, Vlachopoulou E, Lokki ML, Nieminen MS, Klingenberg R, Matter CM, Hornemann T, Jüni P, Rodondi N, Räber L, Windecker S, Gencer B, Pedersen ER, Tell GS, Nygård O, Mach F, Sinisalo J, Lüscher TF. Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol. Eur Heart J. 2016 Jul 1;37(25):1967-76.
• Vaara S, Tikkanen E, Parkkonen O, Lokki ML, Ripatti S, Perola M, Nieminen MS, Sinisalo J. Genetic Risk Scores Predict Recurrence of Acute Coronary Syndrome. Circ Cardiovasc Genet. 2016 Apr;9(2):172-8. doi: 10.1161/CIRCGENETICS.115.001271. Epub 2016 Mar 15.
• Sinisalo J, Vlachopoulou E, Marchesani M, Nokelainen J, Mäyränpää MI, Lappalainen J, Paakkanen R, Wennerström A, Salli K, Niemi HJ, Männistö S, Salo P, Junttila J, Eskola M, Nikus K, Arstila TP, Perola M, Huikuri H, Karhunen PJ, Kovanen PT, Palotie A, Havulinna AS, Lluis-Ganella C, Marrugat J, Elosua R, Salomaa V, Nieminen MS, Lokki ML. Novel 6p21.3 Risk Haplotype Predisposes to Acute Coronary Syndrome. Circ Cardiovasc Genet. 2016 Feb;9(1):55-63.
• Vaara S, Nieminen MS, Lokki ML, Perola M, Pussinen PJ, Allonen J, Parkkonen O, Sinisalo J.  Cohort Profile: the Corogene study. Int J Epidemiol. 2012 Oct;41(5):1265-71.