Publications

Selected Publications.
  • Wang Z, Himanen SV, Haikala HM, Friedel CC, Vihervaara A, Barborič M (2023) Inhibition of CDK12 elevates cancer cell dependence on P-TEFb by stimulation of RNA polymerase II pause release. Nucleic Acids Res 51(20):10970-10991.
  • Wang Z, Mačáková M, Bugai A, Kuznetsov SG, Hassinen A, Lenasi T, Potdar S, Friedel CC, Barborič M (2023) P-TEFb promotes cell survival upon p53 activation by suppressing intrinsic apoptosis pathway. Nucleic Acids Res 51(4):1687-1706.
  • Frilander MJ, Barborič M (2020) The Interlocking Lives of LARP7: Fine-Tuning Transcription, RNA Modification, and Splicing through Multiple Non-coding RNAs. Molecular Cell 78(1):5-8.
  • Bugai A, Quaresma AJC, Friedel CC, Lenasi T, Düster R, Sibley CR, Fujinaga K, Kukanja P, Hennig T, Blasius M, Geyer M, Ule J, Dölken L, Barboric (2019). P-TEFb activation by RBM7 shapes a pro-survival transcriptional response to genotoxic stress. Molecular Cell 74(2):254-267.
  • Quaresma AJC, Bugai A, Barboric M (2016) Cracking the control of RNA polymerase II elongation by 7SK snSNP and P-TEFb. Nucleic Acids Res 44:7527-7539.
  • Barboric M, Fujinaga K (2016) The two sides of Tat. Elife doi:10.7554/eLife.12686.
  • Ekumi KM, Paculova H, Lenasi T, Pospichalova V, Bösken CA, Rybarikova J, Bryja V, Geyer M, Blazek D, Barboric M (2015) Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex. Nucleic Acids Res 43:2575-2589.
  • Barboric M, Lenasi T (2010) Kick-sTARting HIV-1 transcription elongation by 7SK snRNPdeporTATion. Nat Struct Mol Biol 17:928-930.
  • Barboric M, Lenasi T, Chen H, Johansen EB, Guo S, Peterlin BM (2009) 7SK snRNP/P‑TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development. Proc. Natl. Acad. Sci. U S A 106:7798-7803.
  • Barboric M, Yik YHN, Czudnochowski N, Chen R, Yang Z, Contreras X, Geyer M, Peterlin BM, Zhou Q (2007) Tat competes with HEXIM1 to increase the active pool of P-TEFb for HIV-1 transcription. Nucleic Acids Res 35:2003-2012.
  • Barboric M, Kohoutek J, Price J P, Blazek D, Price DH, Peterlin BM (2005) Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb. EMBO J 24:4291-4303.
  • Zhang F*, Barboric M*, Blackwell TK, Peterlin BM (2003) A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb. Genes Dev 17:748-758. (*equal contribution)
  • Barboric M, Nissen R M, Kanazawa S, Jabrane-Ferrat N, Peterlin BM (2001) NF-kB binds P‑TEFb to stimulate transcriptional elongation by RNA polymerase II. Mol Cell 8:327-337.