Welcome to the Barborič Lab pages!

Our mission is to elucidate fundamental mechanisms that control the elongation phase of transcription by RNA polymerase II (Pol II) in normal and disease states. We are particularly interested in essential cyclin-dependent kinases which trigger Pol II release from promoter-proximal pausing and facilitate productive Pol II elongation along genes. Along our journey, we shall reveal basic principles of gene regulation. We aim to exploit the new knowledge to help devise novel treatments of many diseases that stem from misregulated gene transcription programs.
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@BarboricLab

RNA 3' end formation and the regulation of eukaryotic genomes 19 – 23 September 2022 | Oxford, UK. I highly recomm… twitter.com/i/web/status/1…

NEW online: Poly(ADP-ribsoyl)ation of P-TEFb suppresses phase separation to block global transcription after DNA da… twitter.com/i/web/status/1…

By popular demand, here is the list of conferences and schools in the area of gene regulation for the rest of 2022:… twitter.com/i/web/status/1…