A selection of Eskelinen group publications is listed on this page. You can find all our publications in the Helsinki University research database TUHAT.
Highlighted publications
Original articles
Zachari M, Gudmundsson SR*, Li Z*, Manifava M*, Shah R, Smith M, Stronge J, Karanasios E, Piunti C, Kishi‐Itakura C, Vihinen H, Jokitalo E, Guan J-L, Buss F, M. Smith AM, Walker SA, Eskelinen E-L, Ktistakis NT: Selective autophagy of mitochondria on a ubiquitin‐endoplasmic reticulum platform. Dev Cell 2019 (Epub July 15). DOI: 10.1016/j.devcel.2019.06.016
https://www.sciencedirect.com/science/article/pii/S1534580719305696?via%3Dihub
Anwar T, Liu X, Suntio T, Marjamäki A, Biazik J, Chan EYW, Varjosalo M, Eskelinen EL: ER-Targeted Beclin 1 Supports Autophagosome Biogenesis in the Absence of ULK1 and ULK2 Kinases. Cells. 2019 May 17;8(5). DOI: 10.3390/cells8050475.
https://www.mdpi.com/2073-4409/8/5/475
Syrjä P, Anwar T, Jokinen TS, Kyöstilä K, Hultin-Jäderlund K, Cozzi F, Rohdin C, Hahn K, Wohlsein P, Baumgärtner W, Henke D, Oevermann A, Sukura A, Leeb T, Lohi H, Eskelinen E-L: Basal Autophagy is altered in Lagotto Romagnolo Dogs with an ATG4D mutation. Veterinary Pathology 2017, 54:953-963. DOI: 10.1177/0300985817712793
http://journals.sagepub.com/toc/vet/0/0
Biazik J, Vihinen H, Jokitalo E, Eskelinen E-L: Untrastructural characterization of phagophores using electron tomography on cryoimmobilized and freeze substituted samples. Methods Enzymol 2017, 587:331-349.
DOI.org/10.1016/bs.mie.2016.09.063 http://dx.doi.org/10.1016/bs.mie.2016.09.063
Ylä-Anttila P, Mikkonen E, Happonen KE, Holland P, Ueno T, Simonsen A, Eskelinen E-L: RAB24 facilitates clearance of autophagic compartments during basal conditions. Autophagy 2015, 11:1833-48. DOI:10.1080/15548627.2015.1086522.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824578/
Biazik J, Ylä-Anttila P, Vihinen H, Jokitalo E and Eskelinen E-L: Ultrastructural relationship of the phagophore with surrounding organelles. Autophagy 2015, 11:439-451. DOI:10.1080/15548627.2015.1017178.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502653/
Ylä-Anttila P, Vihinen H, Jokitalo E, Eskelinen E-L: 3D tomography reveals connections between the phagophore and endoplasmic reticulum. Autophagy 2009, 5:1180-1185
Reviews
Eskelinen E-L: Autophagy: supporting cellular and organismal homeostasis by self-eating. Int J Biochem Cell Biol 2019, 111:1-10.
https://doi.org/10.1016/j.biocel.2019.03.010
Millan M, Yu WH, Boland B, Cort O, Mollereau B, Henriques A, Bezard E, Pastores G, Rubinsztein D, Nixon R, Duchen M, Mallucci G, Kroemer G, Levine B, Eskelinen EL, Mochel F, Spedding M, Louis C, and Martin O: Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of aging. Nat Rev Drug Disc 2018, 17:660-688.
Ylä-Anttila P, Eskelinen EL: Roles for RAB24 in autophagy and disease. Small GTPases 2018 9:57-65. doi: 10.1080/21541248.2017.1317699.
https://www.ncbi.nlm.nih.gov/pubmed/28463543
Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P2, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen E-L, Fimia GM, Fulda S, Gewirtz DA, Green DR, Hansen M, Harper JW, Jäättelä M, Johansen T, Juhasz G, Kimmelman AC, Kraft C, Ktistakis NT, Kumar S, Levine B, Lopez-Otin C, Madeo F, Martens S, Martinez J, Melendez A, Mizushima N, Münz C, Murphy LO, Penninger JM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Santambrogio L, Scorrano L, Simon AK, Simon HU, Simonsen A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Koemer G: Molecular definition of autophagy and related processes. EMBO J 2017 36:1811-1836. DOI:10.15252/embj.201796697
http://emboj.embopress.org/content/36/13/1811.long
Biazik J, Vihinen H, Anwar T, Jokitalo E, Eskelinen E-L: The versatile electron microscope: an ultrastructural overview of autophagy. Methods 2015, 75:44-53. DOI: 10.1016/j.ymeth.2014.11.013.
http://www.sciencedirect.com/science/article/pii/S1046202314003764
Kaarniranta K, Meri S, Eskelinen E-L: Lääketieteen Nobelin palkinto autofagian tutkijalle / Nobel price in medicine to autophagy researcher. Duodecim 2016, 132:2141-2144. (in Finnish).
http://www.duodecimlehti.fi/lehti/2016/22/duo13396
Damme M, Suntio T, Saftig P, Eskelinen E-L: Autophagy in neuronal cells: General principles and physiological and pathological functions. Acta Neuropathologica 2015, 129:337-362. DOI:10.1007/s00401-014-1361-4.
http://link.springer.com/article/10.1007%2Fs00401-014-1361-4
Eskelinen E-L, Reggiori F, Baba M, Kovács AL, Seglen PO: Seeing is believing – The impact of electron microscopy on autophagy research. Autophagy 2011, 7:935-956.
http://www.tandfonline.com/doi/abs/10.4161/auto.7.9.15760
http://dx.doi.org/10.4161/auto.7.9.15760
Ylä-Anttila P, Vihinen H, Jokitalo E, and Eskelinen E-L: Monitoring autophagy by electron microscopy in mammalian cells. Methods Enzymol 2009, 452:143-164. DOI: 10.1016/S0076-6879(08)03610-0.
http://www.sciencedirect.com/science/article/pii/S0076687908036100
Collaboration
Pascall JC, Webb LMC, Eskelinen E-L, Innocentin S, Attaf N, and Butcher GW: GIMAP6 is required for T cell maintenance and efficient autophagy in mice. PLOS One 2018, 13:e0196504. doi:10.1371/journal.pone.0196504
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196504
Tabara LC, Vicente JJ, Biazik J, Eskelinen E-L, Vincent O, and Escalante R: VMP1 marks ER subdomains enriched in phospholipid synthesizing enzymes and is required for phosphoinositide distribution. Traffic 2018, 19:624-638. https://doi.org/10.1111/tra.12581
https://onlinelibrary.wiley.com/doi/abs/10.1111/tra.12581
Carroll B, Otten EG, Manni D, Stefanatos R, Menzies FM, Smith GR, Jurk D, Kenneth N, Wilkinson S, Passos JF, Attems J, Veal EA, Teyssou E, Seilhean D, Millecamps S, Eskelinen EL, Bronowska AK, Rubinsztein DC, Sanz A, Korolchuk VI: Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis. Nat Commun. 2018 Jan 17;9(1):256. doi: 10.1038/s41467-017-02746-z.
https://www.ncbi.nlm.nih.gov/pubmed/29343728
Kang C, Badr MA, Kyrychenko V, Eskelinen EL, Shirokova N: Deficit in PINK1/PARKIN-mediated mitochondrial autophagy at late stages of dystrophic cardiomyopathy. Cardiovasc Res. 2018 Jan 1;114(1):90-102. doi: 10.1093/cvr/cvx201.
https://www.ncbi.nlm.nih.gov/pubmed/29036556
Colecchia D, Stasi M, Leonardi M, Manganelli F, Nolano M, Veneziani BM, Santoro L, Eskelinen EL, Chiariello M, Bucci C: Alterations of autophagy in the peripheral neuropathy Charcot-Marie-Tooth type 2B. Autophagy. 2017 Nov 13:0. DOI: 10.1080/15548627.2017.1388475. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/29130394
Mandell MA, Jain A, Kumar S, Castleman MJ, Anwar T, Eskelinen E-L, Johansen T, Prekeris R, and Deretic V: TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation. J Cell Sci 2016, 129:3562-3573. DOI: 10.1242/jcs.190017.
http://jcs.biologists.org/content/129/19/3562.long
Frankel LB, Di Malta C, Wen J, Eskelinen E-L, Ballabio A and Lund AH: A non-conserved miRNA regulates lysosomal function and impacts on a human lysosomal storage disorder. Nature Communications 2014, 5:5840. DOI: 10.1038/ncomms6840.
http://www.nature.com/articles/ncomms6840
He C, Wei Y, Sun K, Li B, Dong X, Zou Z, Liu Y, Kinch LN, Khan S, Sinha S, Xavier RJ, Grishin NV, Xiao G, Eskelinen E-L, Scherer PE, Whistler JL and Levine B: Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism. Cell 2013, 154:1085-1099. DOI: 10.1016/j.cell.2013.07.035.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231430/
Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A, Rosen J, Eskelinen E-L, Mizushima N, Ohsumi Y, Cattoretti G, Levine B: Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 2003, 112:1809-1820. DOI:10.1172/JCI200320039
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC297002/
Melendez A, Talloczy Z, Seaman M, Eskelinen E-L, Hall DH, Levine B: Autophagy genes are essential for dauer development and lifespan extension in C. elegans. Science 2003, 301:1387-1391. DOI:10.1126/science.1087782.