Treatment for spinal cord injury

Invention: Peptide enhancing the regeneration of neurites upon injury.
Indication: Granted patents.
Project phase: in vivo PoC for the lead compound, SEQ10 in US 9,896,488 exists.

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A spinal cord injury (SCI) damages any part of the spinal cord or nerves at the end of the spinal canal and often causes permanent changes in strength, sensation and other body functions below the site of the injury. In the US alone, there are an estimated 12,500 new cases of SCI each year, with approximately 260,000 individuals afflicted by SCI. Recurring annual costs of caring for patients with chronic SCI is a large economic burden on health care system. Direct medical and disability support costs in the US alone are $14.5 billion per year and the loss of productivity accounts for an additional $5.5 billion annually. At present there are no known ways to reverse damage to the spinal cord. Our research has focused on extracellular matrix components that are relevant in plasticity and regeneration.

Heikki Rauvala
Neuroscience Center, University of Helsinki

Granted EP14 812 998.4 and US 9,896,488

Rauvala et al. Inhibition and enhancement of neural regeneration by chondroitin sulfate proteoglycans. Neural Regen Res (2017)

Paveliev et al. HB-GAM (pleiotrophin) reverses inhibition of neural regeneration by the CNS extracellular matrix. Sci
Rep (2016)