Laboratory of Docent Daniela Ungureanu and Professor Jussi Taipale at the Medical Systems Biology group (https://www2.helsinki.fi/en/researchgroups/medical-systems-biology ) at the Applied Tumour Genetic Program at University of Helsinki, Faculty of Medicine invites applications for the position of

DOCTORAL STUDENT

Our research group is part of the Academy of Finland's Center of Excellence in Tumour Genetics Research. The laboratory focuses on the study of transcriptional control of cell growth, using functional genomics and systems biology. Current lines of work include high-throughput determination of binding sites and binding specificities of human transcription factors, using this information to identify regulatory elements that control cell growth during normal development or in cancer. We are also working on pharmaco-genomic studies of drug resistance mechanisms in cancers such as ovarian cancer.

Applicants with strong backgrounds in molecular biology/bioinformatics who are interested in working in an inter-disciplinary environment are particularly encouraged to apply.

Applicants should hold a Master’s degree in a field that is relevant to the research topic and have a high quality research proposal. Relevant disciplines include molecular biology, biochemistry, bioinformatics. Other requirements include proven ability and motivation, demonstrated through previous degree studies or otherwise, to pursue postgraduate studies and a doctoral degree according to the study plan and research proposal. Applicant must be able to work independently and have good communication skills in English.

The appointee should either already have the right to pursue a doctoral degree at the University of Helsinki by the start of the appointment or apply for the right and obtain it within the probationary period of six months of their appointment. If the candidate does not already have the right to pursue a doctoral degree at the University of Helsinki, it must be applied for separately, https://www.helsinki.fi/en/admissions-and-education/apply-doctoral-progr...

The appointment will be for 4 years starting upon agreement. Trial period of 6 months will be applied. The monthly gross salary will be appr. 2200-2400 € per month depending on the appointee’s qualifications and experience. In addition, University of Helsinki offers comprehensive services to its employees, including occupational health care and opportunities for professional development. Further information at www.helsinki.fi/en/about-us/careers.

For additional information about the position, please contact Dr. Daniela Ungureanu: daniela.ungureanu (at) helsinki.fi. For additional information about the application process, please contact HR Specialist Päivi Sinisalo: paivi.sinisalo (at) helsinki.fi.

Please submit your application as a single PDF file containing your CV and two letters of reference through the University’s electronic recruitment system by clicking “Apply for the position” link below. Internal applicants (i.e., current employees of the University of Helsinki) must submit their applications through the SAP HR portal, under the tab “Career and Job”. If you have questions about the recruitment system, please contact rekrytointi@helsinki.fi.

The deadline for applications is 30 April 2021.

Selected publications from Taipale lab:

Zhu et al. The interaction landscape between transcription factors and the nucleosome. Nature. 2018, Oct, 76-81.

Yin et al. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science, 2017, May 5;356(6337).

Nitta et al. Conservation of transcription factor binding specificities across 600 million years of bilateria evolution. Elife. 2015 Mar 17;4.

Turunen et al. (2014) Uterine Leiomyoma-Linked MED12 Mutations Disrupt Mediator-Associated CDK Activity. Cell Rep 7, 654–60.

Yan et al. (2013) Transcription factor binding in human cells occurs in dense clusters formed around cohesin anchor sites. Cell 154, 801-13.

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Due date

30.04.2021 23:59 EEST