Translational Medicine

Neurological disorders constitute a major health and economic challenge for Western societies. In addition, advanced parental age, typical in developed societies, is associated with adverse effects on children. Novel treatments and preventive strategies are urgently needed.

Domesticated animals have been exposed to similar environmental factors as humans, and have experienced similar social evolution. This has resulted in highly uniform genomes which are ideal for mapping complex traits with a strong genetic disposition, such as behavioral disorders and reproductive and metabolic diseases.

A threat is also posed by (re-)emerging infections due to globalization and associated environmental changes, including climate change and changes in animal husbandry. Most emerging human infections are caused by zoonotic and vector-borne pathogens, such as the public health emergencies caused by SARS and Zika. Several food-borne zoonotic and veterinary pathogens are also of concern.

Helsinki One Health initiative will utilize the well-documented genetic background of domesticated animals combined with their rigorously controlled health to understand the link between genetic background and disposition to disease and test the causality between the two by using state-of-the-art molecular biological and imaging approaches applied in in vivo, ex vivo and in vitro animal models. The research will also employ cutting-edge tools such as metagenomic pathogen discovery to enable rapid detection and control of emerging infections.

Principal investigators

Tero
Ahola
University Lecturer
Department of Microbiology
Field of science Microbiology and virology, Biochemistry, cell and molecular biology
MA
Marja
Airaksinen
Professor
Division of Pharmacology and Pharmacotherapy
Field of science Pharmacy
Leena
Hanski
University Lecturer
Division of Pharmaceutical Biosciences
Field of science Pharmacy, Microbiology and virology
MH
Markku
Heikinheimo
Field of science Gynaecology and paediatrics
JH
Jussi
Hepojoki
Academy Research Fellow
Department of Virology
Field of science Biomedicine
Anna
Hielm-Björkman
Clinical Instructor
Equine and Small Animal Medicine
Field of science Veterinary science
Anna-Riia
Holmström
Assistant Professor
Division of Pharmacology and Pharmacotherapy
Field of science Pharmacy
Michael
Jeltsch
Associate Professor
Division of Pharmaceutical Biosciences
Field of science Biochemistry, cell and molecular biology, Biomedicine, Pharmacy
AJ
Anne
Juppo
Professor
Division of Pharmaceutical Chemistry and Technology
Field of science Pharmacy
Hannes
Lohi
Professor
Veterinary Biosciences
Field of science Biomedicine, Genetics, developmental biology, physiology, Veterinary science, Neurosciences
AM
Anna
Mykkänen
Assistant Professor
Equine and Small Animal Medicine
Field of science Veterinary science
TO
Timo
Otonkoski
Professor
Children's Hospital
Field of science Neurosciences, Genetics, developmental biology, physiology, Biomedicine
Anu-Katriina
Pesonen
Professor
Department of Psychology and Logopedics
Field of science Psychology, Neurology and psychiatry
Raimo
Pohjanvirta
Professor
Food Hygiene and Environmental Health
Field of science Veterinary science
Tarja
Pääkkönen
Assistant Professor
Equine and Small Animal Medicine
Field of science Veterinary science
Marja
Raekallio
University Lecturer
Equine and Small Animal Medicine
Field of science Veterinary science
MR
Minna
Rajamäki
Clinical Instructor
Equine and Small Animal Medicine
Field of science Veterinary science
Helder
Almeida Santos
Professor
Division of Pharmaceutical Chemistry and Technology
Field of science Pharmacy, Nano-technology, Chemical engineering, Medical biotechnology
HS
Hannu
Sariola
Professor
Department of Biochemistry and Developmental Biology
Field of science Biomedicine
Salla
Sariola
Academy Research Fellow
Sociology
Field of science Sociology
Tarja
Sironen
Associate Professor
Department of Virology
Field of science Biomedicine, Veterinary science, Microbiology and virology
Mikael
Skurnik
Research Director
Human Microbiome Research
Field of science Biochemistry, cell and molecular biology, Biomedicine
TS
Thomas
Spillmann
Professor
Equine and Small Animal Medicine
Field of science Veterinary science
Antti
Sukura
Professor
Veterinary Biosciences
Field of science Veterinary science
TT
Tomi
Taira
Professor
Veterinary Biosciences
Field of science Neurosciences
ST
Sari
Tojkander
Veterinary Biosciences
Field of science Veterinary science
OV
Outi
Vainio-Kivinen
Equine and Small Animal Medicine
Field of science Veterinary science
OV
Olli
Vapalahti
Professor
Department of Virology
Field of science Biomedicine, Veterinary science
Marko
Virta
Professor
Department of Microbiology
Field of science Microbiology and virology, Environmental sciences, Other agricultural sciences