The High Throughput Biomedicine Unit (HTB) provides high throughput screening approaches of many types:
· Drug Sensitivity and Resistance testing (DSRT assay). A set of clinically relevant and targeted bioactive compounds are tested in a dose response series against patient-derived primary cancer cells or cell-lines, after which responses, typically in the form of DSS:s are calculated for each drug. The standard DSRT assay consists, to date, of 527 drugs in 5 concentrations, on 8 384-well plates. The standard readout in an DSRT assay is cell viability and cell death, but microscopic readouts are also offered. For more detailed information see: Pemovska T. et al. 2013; Pemovska T. et al. 2015.