CoMO organizes annual seminars from the current topics for researchers who use animals in their studies.
CoMO Seminars
"Best practice in pre-clinical animal research: Navigating the guidelines and principles “
Preclinical studies using animal models are an integral part of biomedical research. However, their value is dependent on their scientific validity and reproducibility, which are, in turn, dependent on rigorous study design and reporting. This symposium aims to update on the guidelines developed and recommended for achieving robust research output.
- When: November 10, 2021; 12:30 – 17:00 EET (Finland)
- Where: Zoom-meeting.
- Registration for this meeting is required and open until 14:00 on November 8.
- Please use the e-form for registration https://elomake.helsinki.fi/lomakkeet/113272/lomake.html
- Link for joining the meeting will be sent to the email of registered participant on November 9.
- Organizers: Finnish Reproducibility Network and HiLIFE Comprehensive Model Organisms infrastructure platform
- Further information: vootele.voikar@helsinki.fi
PROGRAM:
12:30-12:55 Hanno Würbel (University of Bern, Switzerland): Making a case for animal research: the 3Vs and 3Rs principles
13:00-13:25 Uli Dirnagl (Charité – Universitätsmedizin Berlin, Germany): From 3R to 6R: Improve the quality and value of animal experiments in biomedicine
13:30-13:55 Adrian Smith (Norecopa, Norway): The PREPARE guidelines for planning animal research: checklists and resources
14:00-14:15 break
14:15-14:40 Matthew Brooke (NC3Rs, London, UK): Introducing the ARRIVE guidelines 2.0: revised guidelines for reporting animal research
14:45-15:10 Thomas Steckler (Janssen Pharmaceutica NV, Belgium): The EQIPD Quality System
15:15-15:40 Jan Rozman (Czech Centre for Phenogenomics, Czech Republic): Quality principles in INFRAFRONTIER and IMPC - experiences and lessons from international large-scale mouse genomics projects
15:45-16:00 break
16:00-17:00 round-table discussion and Q/A session together with Pirjo Laakkonen and Satu Kuure (Laboratory Animal Center, University of Helsinki) and Cilene de Oliveira (Universidade Federal de Santa Catarina, Brazil)
Links to the relevant literature / web-sites:
Hanno Wurbel - what are the 3Rs and 3Vs https://journals.sagepub.com/doi/full/10.1177/0023677220968583
Uli Dirnagl – what are the 3Rs missing https://openscience.bmj.com/content/3/1/e000048
Adrian Smith – PREPARE https://norecopa.no/prepare
Matthew Brooke – ARRIVE https://arriveguidelines.org/
Thomas Steckler - EQIPD Quality System https://elifesciences.org/articles/63294
Jan Rozman – Infrafrontier quality principles https://link.springer.com/article/10.1007%2Fs00335-021-09892-2
Rigor, reproducibility and data management in nonclinical research
Malcolm Macleod (University of Edinburgh) - Why changes in research practice are needed now and one cannot wait until tomorrow?
Thomas Steckler (Janssen Pharmaceutica NV) - The need to recognize "research conducted with sufficient rigor"
Vootele Voikar & Andreas Scherer (HiLIFE) - Do we need a reproducibility network in Finland?
Valentina Vengeliene (Vilnius University) - Rigor in collaborative research
Ethics, transparency and rigor in research with animal models
Ulrich Dirnagl (Charité Universitätsmedizin Berlin, Germany):
“Your lab is closer to the patient bed than you think”
Merel Ritskes-Hoitinga (Radboud University Medical Center, The Netherlands):
“How can preclinical systematic reviews improve ethics, transparency and rigor in research?”
Lluis Montoliu (Centro Nacional de Biotecnologia (CNB-CSIC), Madrid, Spain):
“Transparency agreement on animal research - 3 years of experience in Spain”
Satu Kuure (University of Helsinki):
“Ethics and assurity of genome editing in CRISPR era”
“Ethics and assurity of genome editing in CRISPR era”
Hanna-Marja Voipio (University of Oulu):
“Severity classification – nuisance or beneficial tool in experiments?”
“Severity classification – nuisance or beneficial tool in experiments?”
Kirk Leech (The European Animal Research Association):
“Animal Research: Time to Talk!”
“Animal Research: Time to Talk!”
Reproducibility and reliability of animal experiments
Timo Nevalainen (Prof. emeritus, Laboratory Animal Center, University of Eastern Finland):
"Why and how laboratory animals are being used?"
"Why and how laboratory animals are being used?"
Emily Sena (Centre for Clinical Brain Sciences, University of Edinburgh, UK):
"Navigating preclinical research: directions from meta-research"
Adrian Smith (Norecopa and Norwegian Veterinary Institute, Norway):
"PREPARE before you ARRIVE: how to plan animal experiments from day one"
Natasha Karp (Quantitative Biology, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, UK): "Standardization - a cause of poor replicability?"
Ville Hietakangas (Department of Biosciences and Institute of Biotechnology, Head of Drosophila Lab, University of Helsinki): "Controlled genetic experiments with Drosophila"
Peter Hohenstein (Leiden University Medical Center, The Netherlands):
"Use of GM-models in biomedical studies: 3R rule in scientifically sound research"
"Use of GM-models in biomedical studies: 3R rule in scientifically sound research"