CoMO Seminars

"Best practice in pre-clinical animal research: Navigating the guidelines and principles “

Preclinical studies using animal models are an integral part of biomedical research. However, their value is dependent on their scientific validity and reproducibility, which are, in turn, dependent on rigorous study design and reporting. This symposium aims to update on the guidelines developed and recommended for achieving robust research output.

When: November 10, 2021; 12:30 – 17:00 EET (Finland)
Organizers: Finnish Reproducibility Network and HiLIFE Comprehensive Model Organisms infrastructure platform

Further information: vootele.voikar@helsinki.fi

Hanno Würbel (University of Bern, Switzerland): Making a case for animal research: the 3Vs and 3Rs principles

Uli Dirnagl (Charité – Universitätsmedizin Berlin, Germany): From 3R to 6R: Improve the quality and value of animal experiments in biomedicine

Adrian Smith (Norecopa, Norway): The PREPARE guidelines for planning animal research: checklists and resources

Matthew Brooke (NC3Rs, London, UK): Introducing the ARRIVE guidelines 2.0: revised guidelines for reporting animal research

Thomas Steckler (Janssen Pharmaceutica NV, Belgium): The EQIPD Quality System

Jan Rozman (Czech Centre for Phenogenomics, Czech Republic): Quality principles in INFRAFRONTIER and IMPC - experiences and lessons from international large-scale mouse genomics projects

 

Links to the relevant literature / web-sites:

Hanno Wurbel - what are the 3Rs and 3Vs
https://journals.sagepub.com/doi/full/10.1177/0023677220968583

Uli Dirnagl – what are the 3Rs missing
https://openscience.bmj.com/content/3/1/e000048

Adrian Smith – PREPARE
https://norecopa.no/prepare  

Matthew Brooke – ARRIVE
https://arriveguidelines.org/

Thomas Steckler  - EQIPD Quality System
https://elifesciences.org/articles/63294

Jan Rozman  – Infrafrontier quality principles
https://link.springer.com/article/10.1007%2Fs00335-021-09892-2

Rigor, reproducibility and data management in nonclinical research

 
Malcolm Macleod (University of Edinburgh) - Why changes in research practice are needed now and one cannot wait until tomorrow?
 
 
Thomas Steckler (Janssen Pharmaceutica NV) - The need to recognize "research conducted with sufficient rigor"
 
 
Vootele Voikar & Andreas Scherer (HiLIFE) - Do we need a reproducibility network in Finland?
 
 
Valentina Vengeliene (Vilnius University) - Rigor in collaborative research

Ethics, transparency and rigor in research with animal models

 

Ulrich Dirnagl (Charité Universitätsmedizin Berlin, Germany):
“Your lab is closer to the patient bed than you think”

Merel Ritskes-Hoitinga (Radboud University Medical Center, The Netherlands):
“How can preclinical systematic reviews improve ethics, transparency and rigor in research?”

Lluis Montoliu (Centro Nacional de Biotecnologia (CNB-CSIC), Madrid, Spain):
“Transparency agreement on animal research - 3 years of experience in Spain”

 
Satu Kuure (University of Helsinki):
“Ethics and assurity of genome editing in CRISPR era”
 
 
Hanna-Marja Voipio (University of Oulu):
“Severity classification – nuisance or beneficial tool in experiments?”
 
 
Kirk Leech (The European Animal Research Association):
“Animal Research: Time to Talk!”
 
 
 

Reproducibility and reliability of animal experiments

 
Timo Nevalainen (Prof. emeritus, Laboratory Animal Center, University of Eastern Finland):
"Why and how laboratory animals are being used?"
 
Emily Sena (Centre for Clinical Brain Sciences, University of Edinburgh, UK):
"Navigating preclinical research: directions from meta-research"
 
 
Adrian Smith (Norecopa and Norwegian Veterinary Institute, Norway):
"PREPARE before you ARRIVE: how to plan animal experiments from day one"
 
 
Natasha Karp (Quantitative Biology, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, UK): "Standardization - a cause of poor replicability?"
 
 
Ville Hietakangas (Department of Biosciences and Institute of Biotechnology, Head of Drosophila Lab, University of Helsinki): "Controlled genetic experiments with Drosophila"
 
 
Peter Hohenstein (Leiden University Medical Center, The Netherlands):
"Use of GM-models in biomedical studies: 3R rule in scientifically sound research"