Markku Varjosalo: Molecular Systems Biology & Pathology

Welcome to the Varjosalo Lab. Our longstanding interest is the global and comprehensive understanding of how key cellular signaling molecules; protein kinases, protein phosphatases and transcription factors mediate their signaling potential and how the signaling is changed in diseases in the immuno-oncology axis. For this purpose, we have developed experimental and computational methods to identify the protein-interactions formed by these signaling molecules. Additionally, we employ quantitative mass spectrometry -based proteomics on assessing the protein abundance changes, as well as phosphorylation status of the tissues/cells. Furthermore, combining the data from the different sets of ‘omics’ data (proteomics, HTS and HiSeq), allows us to generate global and systems level understanding on how disease-causing mutations mediate their effects, enabling also the development of therapeutic or diagnostic approaches. 

Read more about Markku's and his group's research:


Markku Varjosalo, PhD
Research Director
Institute of Biotechnology, HiLIFE
Biocenter 3, room 3318
P.O. Box 65 (Viikinkaari 1)
00014 University of Helsinki
Email: markku.varjosalo(at)
Phone: +358 2941 59413
fax: +358 2941 59416

Lab manager Sini Miettinen´s phone:  +358 294159414