Markku Varjosalo: Molecular Systems Biology & Pathology

Welcome to the Varjosalo Lab. Our longstanding interest is the global and comprehensive understanding of how key cellular signaling molecules; protein kinases, protein phosphatases and transcription factors mediate their signaling potential and how the signaling is changed in diseases in the immuno-oncology axis. For this purpose, we have developed experimental and computational methods to identify the protein-interactions formed by these signaling molecules. Additionally, we employ quantitative mass spectrometry -based proteomics on assessing the protein abundance changes, as well as phosphorylation status of the tissues/cells. Furthermore, combining the data from the different sets of ‘omics’ data (proteomics, HTS and HiSeq), allows us to generate global and systems level understanding on how disease-causing mutations mediate their effects, enabling also the development of therapeutic or diagnostic approaches. 

Read more about Markku's and his group's research:

Markku is a Principal Investigator/Research Director at BI and the Director of the Viikki Proteomics Unit.  

Contact
Markku Varjosalo, PhD
Research Director
Institute of Biotechnology, HiLIFE

Biocenter 3, room 3318
P.O. Box 65 (Viikinkaari 1)
00014 University of Helsinki
Finland

Email: markku.varjosalo(at)helsinki.fi
Phone: +358 2941 59413
fax: +358 2941 59416

Lab manager Sini Miettinen´s phone:  +358 294159414