HiLIFE contains the Institute for Molecular Medicine Finland FIMM, Institute of Biotechnology (BI) and Neuroscience Center (NC) as units. These units play an important role in developing a strong international research environment in their focus areas and bring important expertise to HiLIFE in recruitment, training, core facilities, innovation, and international cooperation.

 The Institute of Biotechnology is located on the Viikki campus together with several faculties, governmental research institutes LUKE and EVIRA and companies. The Institute of Molecular Medicine Finland FIMM and Neuroscience Center are located on the Meilahti campus together with the Faculty of Medicine, the Helsinki University Hospital and other organizations. 

HiLIFE's umbrella activities enhance cross-border interdisciplinary life science research and elevate the quality of research also across the six life science faculties at the University.