The main research fields at the Department are artificial intelligence, big data frameworks, bioinformatics, data analysis, data science, discrete and machine learning algorithms, distributed, intelligent, and interactive systems, networks, security, and software and database systems.  Many researchers collaborate with colleagues from other universities and from industry.

Helsinki Institute for Information Technology HIIT (joint operation with Aalto University) is collacated with the Department. Some research groups of the Department are integral part of HIIT.

The research groups are divided roughly by their main research methods into four research areas (algorithms, artificial intelligence, networks, and software); some groups work actively on many areas.  The collaboration between the groups is also represented in bigger units such as Helsinki Centre for Data Science (HiData), Finnish Center for Artificial Intelligence (FCAI), Helsinki-Aalto Center for Information Security (HAIC), Foundations of Computational Health (FCHealth) programme, and the Bioinformatics research community.